HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection
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منابع مشابه
HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.
An HPLC-peroxyoxalate chemiluminescence (PO-CL) method for simultaneous determination of methylphenidate (MPH) and ritalinic acid (RA) was developed. The method was used to monitor MPH and RA after administration of MPH to rats. Deproteinized plasma spiked with 1-(3-trifluoromethylphenyl)piperazine (IS) was dried and labeled with 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-...
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متن کاملGas-liquid chromatographic procedure for measurement of methylphenidate hydrochloride and its metabolite, ritalinic acid, in urine.
A gas-liquid chromatographic procedure has been developed for measuring methyiphenidate and its metabolite, ritalinic acid, in urine. The unchanged drug is extracted into chloroform from alkalinized urine together with an internal standard, diphenhydramine. The solvent is removed, the residue dissolved in ethanol, and aliquots are injected into a gas-chromatographic Column containing 3% OV-1 7....
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2011
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-011-4713-0